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The Effects of Pressure Overload on Cardiac Geometry and Function are Aggravated by Aging
Author(s) -
Boer Martine,
Deel Elza D.,
Horst Gijsbertus T.J.,
Hoeijmakers Jan H.J.,
Duncker Dirk J.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.596.2
Subject(s) - pressure overload , cardiology , medicine , heart failure , concentric hypertrophy , diastole , muscle hypertrophy , constriction , cardiac function curve , blood pressure , cardiac hypertrophy
The aging heart undergoes structural and functional alterations, which are reminiscent of changes observed in the failing heart, and may thus increase the vulnerability of the aging heart to develop heart failure in response to mechanical overload. To investigate the effect of aging on left ventricular (LV) remodeling and dysfunction we subjected mice to pressure overload by transverse aortic constriction (TAC) at 3 and 24 months of age. Eight weeks after TAC, LV geometry, LV function and heart as well as lung weights were measured. Aging minimally affected cardiac geometry and function in sham operated animals. TAC not only induced LV hypertrophy, but also reduced fractional shortening in both age groups. However, only in 24 months old mice, TAC induced LV dilation from 3.5±0.2 mm in Sham mice to 4.4±0.2 mm in TAC mice and systolic dysfunction, demonstrated by a decrease in the rate of rise of LV pressure at 40 mmHg (dP/dt P40 ; Sham 7910±460 vs. TAC 4940±360 mmHg/s) as well as diastolic dysfunction evidenced by a decrease in dP/dt min (Sham −6810±430 vs. TAC −5025±462 mmHg/s) and an increase in LV end diastolic pressure from 5±1 mmHg in Sham mice to 12±3 mmHg in TAC mice (all p<0.05). In conclusion, the effects of pressure overload on cardiac geometry and function are aggravated by aging.