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Relationship between total peripheral resistance and measures of central artery wave reflection
Author(s) -
Shepherd John RA,
Hart Emma C.,
Curry Timothy B.,
Charkoudian Nisha,
Joyner Michael J.,
Casey Darren P.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.594.7
Subject(s) - radial artery , aortic pressure , cardiology , blood pressure , pulse pressure , pulse wave velocity , medicine , artery , aorta , cardiac output , peripheral , arterial stiffness , waveform , applanation tonometry , physics , quantum mechanics , voltage
We examined the relationship between total peripheral resistance (TPR) and central artery pressure and indices of wave reflection in 16 subjects (10F/6M; 26 ± 1 yr). Non‐invasive aortic pressure waveforms were synthesized from high‐fidelity radial pressure waveforms obtained from applanation tonometry of the radial artery. Radial blood pressure (BP) was calibrated from brachial artery BP (catheter). Central artery pressures, aortic augmentation index (AI a ), roundtrip travel time of the reflected wave to and from the periphery (Δt p ; inverse of pulse wave velocity), and wasted left ventricular energy (E w ) were calculated from the generated aortic pressure waveform. Cardiac output (CO) was measured using an open‐circuit acetylene uptake technique and used to calculate total peripheral resistance (mean arterial pressure/CO). TPR was positively related to aortic pulse pressure (r = 0.49), augmented pressure of the central artery wave (r = 0.60), pulse pressure amplification (r =0.54), AI a (r = 0.53), and E w (r = 0.66), (P < 0.05 for all). Additionally, TPR was inversely related to Δt p (r = − 0.51, P < 0.05). Our data suggests that increased levels of TPR are related to measures of central artery pressure, wave reflection characteristics and indices of central artery stiffness. Supported by NIH K23 DK‐082424 (TBC), AHA 2170087(ECH) and CTSA RR‐024150