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Effect of Cuscuta chinensis on renal function in ischemia/reperfusion‐induced acute renal failure rats
Author(s) -
Shin Sun,
Lee An Sook,
Kim Eun Ju,
Kang Dae Gill,
Lee Ho Sub
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.591.16
Subject(s) - renal function , chemistry , kidney , renal ischemia , blood urea nitrogen , reabsorption , creatinine , urea , fractional excretion of sodium , urine , pharmacology , excretion , medicine , endocrinology , ischemia , biochemistry , reperfusion injury
The kidneys play the central role in regulating the water, ion composition and excrete metabolic waste products into the urine. Cuscuta chinensis has been known as an important traditional Chinese medicine for controlling urination. Thus, we designed to examine whether aqueous extract of Cuscuta chinensis (ACC) has an effect on renal function parameters in ischemia/reperfusion (I/R)‐induced acute renal failure (ARF) rats. Administration of ACC (250 mg/kg/day) for 4 days showed that renal functional parameters including urinary excretion rate, osmolality, Na + , K + , Cl − , creatinine clearance, solute‐free water reabsorption and blood urea nitrogen were significantly recovered in I/R‐induced ARF. Periodic acid Schiff (PAS) staining showed that administration of ACC improved tubular damage I/R‐induced ARF. In immunoblot and immunohistological examination, I/R‐induced ARF decreased the expressions of water channel (AQP 2, 3) and sodium potassium pump (Na,K‐ATPase) in renal medulla. However, administration of ACC markedly incremented AQP 2, 3 and Na,K‐ATPase expression. Therefore, these data indicate that administration of ACC ameliorates regulating the urine concentration and renal functions in rats with I/R‐induced ARF.