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Gender Differences in Cardiac Responses to Catecholamine Stress in Caloric Restricted Mice
Author(s) -
Yan Lin,
Gao Shumin,
Lai Lo,
Ge Hui,
Hong Chull,
Vatner Dorothy E.,
Vatner Stephen F.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.588.3
Subject(s) - medicine , catecholamine , ejection fraction , endocrinology , caloric theory , heart failure , longevity , chronic stress , gerontology
Caloric restriction (CR) is the most extensively studied intervention that extends longevity and protects against stress. Generally, women show greater longevity and stress protection than men. We examined gender differences in response to the stress of chronic isoproterenol (ISO) infusion (60mg/kg/day for 1 week), delivered by subcutaneous mini‐osmotic pumps, in young male and female mice (3–6 months old, n=13/group) subjected to 6 weeks of CR. LV ejection fraction (LVEF) was similar in female and male mice with CR (70%±2% vs 71%±2%). Surprisingly, at 1 week after ISO, LVEF in CR female mice was lower than that in CR male mice (37%±4% vs 50%±3%, p<0.05), and the females began to develop heart failure, as reflected by higher lung/body weight (8.6±0.4) compared with males (7.9±0.1). Furthermore, ISO‐induced apoptosis was much greater, p<0.05, in CR females (1.67±0.23 positive cells/mm 2 ) than in CR males (0.84±0.17 positive cells/mm 2 ). In contrast to the well established cardiac protection in pre‐menopausal females, our results indicate that CR female hearts demonstrated less tolerance to chronic catecholamine stress than CR male hearts.