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Nicotinic and muscarinic receptors in the rat dorsal hippocampus mediate the conditioned place preference induced by ethanol
Author(s) -
Rostami Parvin,
Zarrindast Mohammad Reza
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.580.7
Subject(s) - muscarinic acetylcholine receptor , mecamylamine , conditioned place preference , chemistry , pharmacology , nicotinic agonist , nicotine , ethanol , pilocarpine , antagonist , endocrinology , hippocampus , receptor antagonist , medicine , receptor , neuroscience , biology , biochemistry , epilepsy
Conditional place preference (CPP) is a behavioral response that can be used to study the neurobiology of reward and addiction behavior. We previously showed that nicotinic receptors in the basolateral amygdale potentiate the ethanol‐induced CPP. This study characterized the role of cholinergic receptors in the dorsal hippocampus in mediating the ethanol‐induced CPP in rats. Daily injection of ethanol (0.25, 0.5, 1 and 1.5 g/kg) s.c. or saline (2 ml/kg) i.p. elicited a dose‐dependent CPP response to ethanol. The maximum response was observed with the 0.5 g/kg ethanol dose, and this dose was used for all further studies. Injections of nicotine (0.5, 0.75 and 1μg/rat) potentiated the ethanol‐induced CPP. Injection of the nicotine receptor antagonist, mecamylamine (1, 2 and 4 μg/rat) inhibited the ethanol induced CPP, as did injection of the muscarinic receptor antagonist atropine (1, 2 and 4 g/rat). Pretreatment with anti‐cholinesterase drug, pilocarpine (0.5, 1 and 1.5 μg/rat) did not alter the ethanol‐induced CPP. This data suggest that both muscarinic and nicotine receptors in the hippocampus may be involved in the acquisition of ethanol induced CPP.