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Improvement of blood rheology by product GRTC in a Metabolic Syndrome aging model
Author(s) -
Yang Jieying,
Tan Ningzhi,
Zhang Yan,
Zhao Chunsheng,
Zhu JiaShi
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.570.8
Subject(s) - hemorheology , oxidative stress , blood viscosity , medicine , glycation , endocrinology , antioxidant , metabolic syndrome , lipid peroxidation , diabetes mellitus , chemistry , biochemistry
Long‐term high‐calorie diet results in metabolic syndrome causing atherosclerosis and shortens the lifespan, due to mitochondria dysfunction, impairment of glucose, lipids and energy metabolisms and increases in oxidative stress and protein glycation (FASEB J 23:578.15, 2009). The atherosclerotic, oxidative and glycation pathology may impair RBC's ability in deformation and aggregation, causing increased blood viscosity and vascular dysfunctions. The benefits of the proprietary product GRTC include antioxidant, improving mitochondria functions on glucose‐lipid‐energy metabolisms, anti‐fatigue and endurance enhancement, and lifespan extension. We further tested the effect of GRTC in lowering blood viscosity in metabolic syndrome rats with elevated plasma AGEs. After on a high‐calorie diet for 44 wks, aged rats with impaired oral glucose tolerance were randomized based on their plasma AGEs fluorescence values into 4 groups, either continuing on the diet (controls) or consuming the same diet mixed with GRTC at a dose of 0.2, 0.4 or 0.8 g/kg. Blood viscosity was examined after 28 wks of GRTC. Compared to controls, GRTC at 0.2g/kg reduced blood viscosity and GRTC at 0.2 & 0.8g/kg reduced the AUC of blood viscosity in rats (p<0.05), with improvement of both high‐shear and low‐shear viscosity. Our findings indicate the benefits of GRTC in hemorheology and reduced risks in vascular diseases.