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Antidiabetic potential of combine aqueous extract of Eugenia jambolana Momordica charantia fruit
Author(s) -
Yele Santosh Umakant
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.569.4
Subject(s) - momordica , streptozotocin , traditional medicine , terpenoid , diabetes mellitus , chemistry , glycogen , aqueous extract , aqueous solution , insulin , medicine , biochemistry , endocrinology
In recent years there has been a renewed interest to screen plant extracts, juices, combinations of two or more plant drugs for a possible beneficial uses in diabetes. Momordica charantia (MC) and Eugenia jambolana (EJ) have been traditionally reported to have antidiabetic property. The objective was to study the effect of aqueous extract of EJ and MC in streptozotocin (STZ) induced diabetic rats The Aqueous extract of Eugenia jambolana bark (EJ) per se and in combination with Momordica charantia fruit extract (MC) was tested for its efficacy in STZ ‐induced (55mg/kg; i.p.) diabetic rats. The aqueous extract was tested for antihyperglycemic activity using glucose tolerance test in rats. The EJ extract (500 mg/kg) per se showed significant antidiabetic property as judged from body weight, serum glucose, lipids, cholesterol and urea, and liver glycogen levels. However, the EJ extract per se did not significantly influence the levels of serum insulin in diabetic rats. The antihyperglycemic activity was found predominantly in the combination of extracts, which may attribute to presence of terpenoids, tannins, poly phenolics and saponins.