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Impact of the Mediterranean diet and weight loss on plasma cell adhesion molecule concentrations in men with the metabolic syndrome
Author(s) -
Richard Caroline,
Couillard Charles,
Royer MarieMichelle,
Desroches Sophie,
Couture Patrick,
Lamarche Benoît
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.564.15
Subject(s) - weight loss , mediterranean diet , medicine , endocrinology , zoology , obesity , biology
This study examined the impact of the Mediterranean diet (MedDiet) consumed under controlled feeding conditions, with and without weight loss, on plasma cell adhesion molecule (CAM) concentrations in men with the metabolic syndrome (MS). Twenty‐six men (age: 24–62 years) with the MS first consumed a control Western‐type diet for 5 weeks followed by a 5‐week MedDiet, both under weight‐maintaining isocaloric feeding conditions. They then underwent a 20‐week caloric restriction phase that led to a 10.2 ± 2.9% reduction in body weight (P <0.01), followed by the consumption of an isocaloric MedDiet for 5 weeks. All foods including red wine were provided during the isocaloric phases of the study. Although there was no change in any of the vascular CAM after the MedDiet without weight loss, participants with high E‐selectin at baseline (above median, 36.8 ng/mL) showed greater reductions in plasma E‐selectin levels on the MedDiet without weigh loss than those with low plasma E‐selectin at baseline (P for interaction <0.01). The MedDiet combined with weight loss reduced plasma intercellular CAM concentrations by 10.9% (P <0.01) compared with the control diet and by 6.8% (P =0.068) compared with the MedDiet without weight loss. These data suggest that weight loss may be required for the MedDiet to improve CAM levels in men with the MS.