Effect of strawberry powder on blood pressure and flow mediated vasodilation in individuals with pre‐hypertension

We previously reported that strawberry (Str) extract induced endothelium dependent relaxation in an ex vivo rabbit aorta model, suggesting a role for Str in blood pressure regulation. Based on this data, we hypothesized that daily consumption of strawberry powder at a dose corresponding to ex vivo results for 8 wks will reduce blood pressure (BP) and increase vessel relaxation (as measured by flow mediated vasodilation, FMD) in pre‐hypertensive [systolic pressure (sys) 120–139 mmHg and diastolic (dia) 80–89 mmHg] men and women. In a randomized, parallel, double‐blind, placebo‐controlled trial, men and women (n=32, 43 ± 12 y) consumed either a placebo (Pbo) or Str (12 g Str powder, ~136 mg flavonoids) beverage matched in energy and macronutrient composition. BP data was collected via 24h ambulatory BP monitors at screening, wks 1, 4, 8, and 4 wks post‐study. FMD was measured at wks −2 and 8. After 8 wks of intervention, the Str group had a 2.1% ± 1.7% mmHg decrease in sys BP and 1.7% mmHg decrease in dia BP corresponding to decreases of 3.2% and 2.1% mmHg when compared to sys and dia BP in subjects consuming Pbo, respectively. FMD increased 3.5% ± 2.1% in women consuming Str and decreased 2.5% ± 1.8% in men; suggesting a diet by sex interaction. More research is needed to strengthen this association; however it appears strawberry consumption may benefit individuals with pre‐hypertension.