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Sex differences in response to a Mediterranean diet on cardiovascular risk profile
Author(s) -
Bédard Alexandra,
Riverin Mélissa,
Dodin Sylvie,
Corneau Louise,
Lemieux Simone
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.564.1
Subject(s) - mediterranean diet , medicine , metabolic syndrome , apolipoprotein b , endocrinology , cholesterol , insulin , insulin resistance , plasma glucose , lipid profile , diabetes mellitus
Objective To investigate differences between men and women with regard to changes in metabolic parameters associated with cardiovascular risks in response to a 4‐week eucaloric controlled nutritional intervention based on the traditional Mediterranean diet. Methods Participants were men and premenopausal women who had a slightly elevated plasma LDL‐cholesterol concentration (between 3.4 and 4.9 mM) and at least one factor of the metabolic syndrome. During the intervention, all foods and drinks concordant with the traditional Mediterranean diet were provided to participants. Metabolic parameters were measured before and after the controlled intervention. These preliminary analyses included data from 23 men and 16 women. Results Compared with baseline, plasma concentrations of total cholesterol, LDL‐cholesterol and apolipoprotein‐B significantly decreased in both men and women (respectively 9%, 10% and 9% for men and 9%, 9% and 12% for women; P<0.05). Significant decreases in area under the insulin curve and a significant improvement in insulin sensitivity were observed only in men (P<0.05). Conclusion According to our preliminary results, consuming a traditional Mediterranean diet leads to significant changes in plasma lipid‐lipoprotein profile in both men and women. Significant improvements in plasma glucose–insulin homeostasis were observed, but in men only. Supported by CIHR and HSFC