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Association of 25‐hydroxyvitamin D (25‐OH‐D) with Lung Function in the Health, Aging and Body Composition (Health ABC) Study
Author(s) -
Reardon Brian J,
Kritchevsky Stephen B,
Harris Tamara,
Houston Denise K,
Bauer Doug,
Koster Annemarie,
Newman Anne,
Cassano Patricia A
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.562.6
Subject(s) - medicine , vitamin d and neurology , lung function , copd , body mass index , vital capacity , demography , physical therapy , lung , diffusing capacity , sociology
Low forced expiratory volume in 1 second, FEV1, is a risk factor for chronic obstructive pulmonary disease (COPD). Vitamin D may protect lung tissue through modulation of inflammation and tissue remodeling processes. We investigated the association of serum 25‐OH‐D, measured at the year 2 exam, with FEV1 measured at study entry, in well‐functioning adults aged 70–79 enrolled in the Health ABC Study. 2,122 participants had measured serum 25‐OH‐D, acceptable FEV1 quality, and no evidence of prevalent COPD. The association of 25‐OH‐D with lung function was estimated in regression models, which were adjusted for age, sex, height, race, smoking, body mass index, season, site, and physical performance. A strong positive, nonlinear association of 25‐OH‐D with FEV1 (p=.0054) was evident; the FEV1 in participants with inadequate 25‐OH‐D (<10 ng/mL) was 215.5 mL lower than the FEV1 in participants with 'adequate' 25‐OH‐D (>=30 ng/mL). Mean serum 25‐OH‐D was lower in African Americans (21.1 ng/mL) compared to Whites (28.8 ng/mL), but neither race, gender nor smoking modified the association of 25‐OH‐D with FEV1. These results, combined with other published evidence, suggest the possibility of lifestyle intervention in the elderly to preserve lung health. Funding: This project was supported by NIA contracts N01‐AG‐6‐2101, N01‐AG‐2103, N01‐AG‐6‐2106 and R01 HL74104.