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Dietary total antioxidant capacity is inversely associated with the risk of cardiovascular disease in U.S. adults
Author(s) -
Yang Meng,
Chung SangJin,
Chung Chin Eun,
Song Won O.,
Chun Ock K.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.560.2
Subject(s) - medicine , odds ratio , vitamin c , antioxidant , biomarker , antioxidant capacity , population , physiology , endocrinology , environmental health , oxidative stress , biology , biochemistry
Dietary total antioxidant capacity (TAC) and serum concentrations of homocystein (Hcy) and C‐reactive protein (CRP) have been addressed related to CVD; however, no documents reported the relationship between dietary TAC levels and these serum biomarkers in a large scale, free living population. The study aimed to investigate the association between the dietary TAC level and serum Hcy and CRP concentrations of US adults. The USDA flavonoid and proanthocyanidin databases, dietary supplement data and food consumption data of 4,391 U.S. adults aged ≥ 19 yrs in NHANES 2001–2002 were utilized. Previously measured vitamin C equivalent antioxidant capacity of 43 nutrients was applied. Serum CRP concentrations were higher in women, blacks, smokers, those with higher BMI, higher total cholesterol to HDL ratio, lower exercise levels and taking NASID and the subjects who had inflammatory chronic diseases (p<0.05). Higher daily dietary TAC level was inversely associated with odds ratio for Hcy ≥ 13 μmol/L (p<0.001) and odds ratio for CRP ≥ 3 mg/L (p<0.1) after adjusting for relevant covariates. Our present study demonstrated that total TAC from diet and dietary supplements was inversely associated with the risk of CVD in U.S. adults. The potential benefit of dietary TAC as a biomarker of dietary antioxidant intake status and CVD risk needs further research. Grant Funding Source : American Heart Association