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Chokeberry extract consumption inhibits weight gain by modulating adipogenesis, insulin signaling, and inflammatory related gene expression in adipose tissue in rats fed a fructose rich diet
Author(s) -
Qin Bolin,
Anderson Richard A
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.555.7
Subject(s) - endocrinology , medicine , adipogenesis , insulin resistance , adiponectin , weight gain , adipose tissue , insulin , adipocyte , insulin receptor , fructose , peroxisome proliferator activated receptor gamma , irs1 , biology , chemistry , peroxisome proliferator activated receptor , biochemistry , body weight , receptor
Chokeberries are a rich source of anthocyanins which may contribute to the prevention of weight gain and obesity. The aim of present study was to determine if an extract from chokeberries inhibits weight gain in rats fed a fructose‐rich diet (FRD, 60%) and explore the potential molecular mechanisms related to adipogenesis, insulin signaling, and inflammatory related pathways in epididymal adipose tissue (EAT). Chokeberry extract (CB, CellBerry®, 200 mg/kg daily) was added to the drinking water for 6 wks in rats made insulin resistant by feeding a FRD. Chronic CB intake lowered body weight gain, epididymal fat accumulation, blood glucose, triglycerides, cholesterol, and LDL‐C in the FRD‐induced insulin resistant rats and improved glucose intolerance and elevated plasma adiponectin levels. Gene expression of adiponectin, PPARg, IRS1, IRS2, PI3K, and glycogen synthesis 1 were all improved by the CB supplement. The levels of adipocyte gene expression of inflammatory genes such as IL‐1b, IL‐6 and TNF‐α were lowered by CB. In summary, these results suggest that the chokeberry extract (CellBerry®) inhibited weight gain in FRD‐induced insulin resistant animals, and decreased risk factors related to insulin resistance by modulating multiple genes associated with adipogenesis, insulin signaling, and inflammation. (Funded by USDA/ARS CRADA No.58‐3K95‐7‐1184 with Integrity Nutraceuticals International).