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The effect of dietary macrocomposition on weight loss and nonalcoholic fatty liver disease (NAFLD) in bariatric surgery candidates.
Author(s) -
Uhley Virginia Ellen,
Neidert Adam,
Birkmeyer John,
Finks Jonathan F,
Burant Charles,
Oral Elif Arioglu
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.555.1
Subject(s) - medicine , weight loss , nonalcoholic fatty liver disease , obesity , surgery , fatty liver , low calorie diet , disease
Most bariatric surgery programs use a conventional low fat, calorie restricted diet during the preparation phase for surgery. However, no systematic comparison of diets with different macronutrient compositions have been performed. We are investigating the clinical effects of a low carbohydrate versus a low fat diet in patients that are preparing for bariatric surgery. Enlarged steatotic livers increase the operative risk of bariatric surgery and weight loss prior to bariatric surgery has been shown to reduce operative risk. We hypothesize that the use of a 1000–1200 kcalorie low carbohydrate diet (< 15% of total kcaloric intake) during the preparation phase for bariatric surgery will cause a greater reduction in weight, hepatic fat content and hepatic volume compared to a “conventional” 1000–1200 kcalorie low‐fat diet (30% fat, 60% carbohydrates of total kcaloric intake) and offer clinical advantages by making the technical aspects of surgery easier. Here we present preliminary data on 8 patients that have finished the study. Our results will provide a basis to help identify the optimal dietary intervention to make bariatric surgery safe and effective for the increasing numbers of patients opting for this aggressive therapy for morbid obesity.