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Menstrual cycle affects postprandial glucose responses to a hyper‐lipidic meal in young adult women
Author(s) -
Silva Iris Lima,
Torres Alexandre Guedes
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.553.5
Subject(s) - postprandial , meal , medicine , endocrinology , luteal phase , area under the curve , follicular phase , basal (medicine) , insulin
Our aim was to investigate in young adult women the influence of the menstrual cycle phase on post‐prandial glycemia and lipemia after a hyper‐lipidic meal. We recruited 14 volunteers not taking oral contraceptives, which were studied during the follicular (FP; 3 rd to 9 th days) and the luteal phases (LP; 17 th to 25 th days). We collected blood samples after an overnight fast at baseline and after the intake of a standardized meal consisting of a high fat milk‐shake, two slices of white bread and 80g of white American cheese, with a total caloric value of 870 kcal, of which 62% were from lipids and 29% from carbohydrates. After the meal, blood samples were taken with 60 min intervals for up to six hours. We did not find significant differences between the FP and the LP for triglyceridemia and glycemia in the basal or the postprandial period. We observed a positive correlation between fasting plasma triglyceridemia and the area under the curve (AUC) of postprandial triglyceridemia during both the FP (r= 0.60, P < 0.05) and the LP (r= 0.80, P < 0.001). In contrast, only in the FP there was a negative correlation (r= −0.78, P < 0.0005) between fasting glycemia and the AUC of postprandial glycemia. We conclude that the influence of fasting glycemia on the postprandial clearance of blood glucose seems to be affected by the menstrual cycle phase.