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Comparison for bioavailability of 1‐deoxynojirimycin with mulberry water extract in rat
Author(s) -
Kim Ji Yeon,
Kwon Hye Jin,
Jung Ji Young,
Kim Do Ram,
Kim Young Suk,
Kwon Oran
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.540.9
Subject(s) - bioavailability , excretion , absorption (acoustics) , urine , chemistry , feces , oral administration , pharmacology , pharmacokinetics , food science , medicine , biology , biochemistry , microbiology and biotechnology , physics , acoustics
The bioavailability of dietary phytochemicals may be influenced by the food matrix in which they are prepared. In this study we compared the intestinal absorption and excretion of orally administered 1‐deoxynojirimycin, which is well known as a potent glucosidase inhibitor, as isolated DNJ and mulberry water extract. When the rats sacrificed after administered mulberry water extract or isolated DNJ at 0, 15, 30, 45, 60, 120, 240, and 360 min, plasma DNJ levels reached a maximum at 30 min and then rapidly decreased. The DNJ levels of plasma 30 min after administration of mulberry leaf extract were lower than isolated DNJ with statistical significance (p<0.05). Moreover, the DNJ was dose‐dependently absorbed from the digestive tract into rat plasma (p<0.0001). We analyzed the concentration of DNJ in plasma, feces, and urine when administered as isolated DNJ as well as mulberry water extract. The absorption and excretion pattern was similar between them. These findings indicate that orally administered mulberry water extract and isolated DNJ are absorbed and excreted as similar pattern and the absorption rate for isolated DNJ is higher than water extract. Grant Funding Source : ASN