Premium
Lifetime Dietary Exposure To Soy Isoflavones Is Beneficial To Prostate And Testicular Health In 100 Day‐Old Male Long‐Evans Rats
Author(s) -
Blake Crystal,
Hansen Tevor,
Hogen Benjamin,
Bourgeois Isaac,
Lephart Edwin D
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.540.6
Subject(s) - seminiferous tubule , endocrinology , medicine , sertoli cell , prostate , isoflavones , testosterone (patch) , leydig cell , spermatogenesis , biology , hormone , luteinizing hormone , cancer
Consumption of soy isoflavones appears to be beneficial for several health parameters. We examined the effect of dietary exposure (from conception) of soy isoflavones on body weight (BW), white adipose tissue (WAT), prostate weight, and testicular weights (TW) and for several morphometric parameters. During pre‐ and postnatal development male rats were exposed to either a phytoestrogen‐rich (PR) or phytoestrogen‐low (PL) diet. At 100 days of age the male rats were sacrificed, tissues weighed, processed and analyzed by histology methods. BW and prostate/BW ratios were slightly decreased in the PR vs. PL groups (but were non‐significant). WAT/BW ratios were significantly less in the PR vs. the PL fed animals. Additionally, the percentage of invaginations of prostate glandular tissue was significantly greater in the PR vs. PL males. TW and TW/BW ratios were significantly greater in the PR vs. PL fed animals. Sertoli cell area was significantly greater in the PR vs. PL animals which accounted for greater seminiferous tubule lumens and seminiferous tubule areas in the PR vs. PL groups. These data indicate that consumption of a soy isoflavone rich diet appears to be beneficial in decreasing prostate glandular tissue and WAT deposition while increasing testicular weight, Sertoli cell area and seminiferous tubule volume which suggest a positive influence on reproductive capacity in males. (Grant Support: USDA 2004‐01811)