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Zinc absorption from traditional meals by vitamin A‐depleted Bangladeshi women is greater in those with altered intestinal permeability, while iron absorption is not affected
Author(s) -
PerezExposito Ana Beatriz,
Woodhouse Leslie,
Haskell Marjorie J,
Jamil Kazi M,
Barfod Gry,
Wahed Mohammed A,
Brown Kenneth H
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.538.6
Subject(s) - intestinal permeability , lactulose , zinc , medicine , bioavailability , chemistry , micronutrient , vitamin , endocrinology , absorption (acoustics) , mannitol , biochemistry , materials science , pharmacology , organic chemistry , composite material
Background Zinc and iron deficiencies have been associated with altered intestinal mucosal function. Objectives To examine the relationship between intestinal permeability and zinc and iron absorption in non‐pregnant, vitamin A‐depleted Bangladeshi women (plasma retinol < 1.05 umol/L). Methods Zinc absorption from a traditional test meal was assessed using the dual stable isotope tracer ratio method, and iron absorption was assessed by erythrocyte incorporation of a stable iron isotope 10 days after the oral dose. Intestinal permeability was evaluated with the lactulose‐mannitol (L:M) test. Results Fractional zinc absorption (FZA) was greater in women with altered intestinal permeability (urinary L:M recovery ratio >0.07) than in women with L:M ≤0.07 [FZA = 36.1 ± 9.4 % vs. 24.9 ± 10.3 %, respectively, p = 0.038]. Iron absorption from meals did not differ by intestinal permeability status [2.9 % (1.4, 5.8) vs 2.6 % (1.8, 3.8) p = 0.79]. Zinc absorption was marginally correlated with the urinary lactulose:creatinine ratio (p = 0.07). Conclusions Zinc absorption from a traditional meal in vitamin A‐depleted Bangladeshi women is greater in those with altered intestinal permeability than in those with normal permeability, but iron absorption is not affected Funding was provided by HarvestPlus. Ana Perez‐Exposito was partially funded by the International Nutrition Foundation/Ellison Medical Foundation.