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Assessment of iron and zinc status of women and their children in Jordan and evaluation of sensitivity and specificity of transferrin receptors in identifying iron deficiency
Author(s) -
Gharaibeh Muna,
Stoecker Barbara J
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.538.5
Subject(s) - ferritin , iron deficiency , soluble transferrin receptor , zinc deficiency (plant disorder) , zinc , transferrin , hemoglobin , medicine , iron status , physiology , endocrinology , anemia , pediatrics , chemistry , organic chemistry
Prevalence of iron and zinc deficiency among women and their preschool children was assessed in Jordan in July 2007. Hemoglobin and plasma ferritin, zinc, transferrin receptors and α‐1‐ acid glycoprotein (AGP) were determined in 93 mothers and their children. Measurements of hemoglobin, ferritin, and zinc showed 29% of mothers and 10% of children to be deficient by at least two parameters, and 24% of mothers and 3% of children were deficient by three parameters. Thirty‐eight women (41%) and 24 children (26%) were anemic. Mothers with ferritin <15 μg/L were 54%, and 16% of children had ferritin <12 μg/L; half of children were below 22 μg/L. Mothers body iron (mean ± SD) was estimated to be significantly lower (0.5 ± 4.9) mg/kg than their children (3.5 ± 3.8) mg/kg; 45% of mothers had an iron deficit of 4.0 mg/kg body weight while 18% of children had an iron deficit of 0.71 mg/kg body weight. More than 50% of mothers and 30% of children had AGP≥1.2 g/L. Plasma zinc was 67.2 ± 11.4 μg/dL in mothers and 64.6 ± 9.4 μg/dL in children. More than half of women (58%) and children (56%) were below iZiNCG cut‐offs for zinc deficiency. Zinc was correlated for mothers and children (r=0.33, p<.005). The performance of three parameters: TfR, TfR/ferritin, and TfR/Log 10 ferritin in detecting iron deficiency among mothers and children was evaluated using receiver operator characteristics (ROC) curves. TfR/ferritin and TfR/Log 10 ferritin appeared to have better diagnostic efficiency in detecting iron deficiency than the use of TfR alone. In summary , co‐existing micronutrient deficiencies were widespread among mothers and children in northern Jordan. (Supported by Oklahoma State Univ).