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Urinary chromium loss associated with diabetes is offset by increases in absorption
Author(s) -
Vincent John B.,
Rhodes Nicholas R.,
McAdory DeAnna,
Love Sharifa,
Di Bona Kristin R.,
Rasco Jane F.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.537.6
Subject(s) - excretion , endocrinology , diabetes mellitus , urinary system , medicine , absorption (acoustics) , chromium , chemistry , insulin resistance , materials science , organic chemistry , composite material
The status of Cr as an essential trace element has been seriously challenged. The evidence is ambiguous, not definitive. Yet, Cr administration to diabetic model animals has been shown to result in improvements in insulin resistance and lipid parameters. As urinary Cr excretion is greater in these models than in controls, Cr has been proposed to be conditionally essential. Cr absorption in these models has not been determined; thus, their Cr status is unknown. Consequently, the absorption and distribution of 51 Cr from a gavage dose of 51 CrCl 3 has been determined in Zucker, Zucker obese and ZDF rats. ZDF rats have increased urinary Cr loss as a result of their diabetes; this loss is offset by increased absorption. Obese rats have altered rates of Cr transport and distribution but have similar urinary Cr loss and absorption to controls. Given that dietary Cr is absorbed with ~1% efficiency, suitable Cr exists in the diet to allow for the increases in absorption associated with diabetes. Consequently, supplementing the diet with nutritionally relevant quantities of Cr is not anticipated to have any beneficial effects. Similarly, beneficial effects from supra‐nutritional doses of Cr(III) complexes do not arise from alleviation of Cr deficiency and must arise from pharmacological effects of high dose Cr(III). This project was supported by NRI Grant 2009‐35200‐05020 from the USDA National Institute for Food and Agriculture.