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Antioxidants induced cytokine alterations indicative of a better prognosis after ACL surgery
Author(s) -
Barker Tyler,
Martins Thomas B.,
Hill Harry R.,
Kjeldsberg Carl R.,
Trawick Roy H.,
Leonard Scott W.,
Walker James A.,
Traber Maret G.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.535.7
Subject(s) - medicine , cytokine , discontinuation , placebo , anterior cruciate ligament , adverse effect , sham surgery , interleukin , randomized controlled trial , anesthesia , gastroenterology , surgery , pathology , alternative medicine
Following anterior cruciate ligament (ACL) surgery, muscle weakness is commonly observed and may be potentiated by pro‐inflammatory cytokines. Because vitamins E and C (AO) reportedly modulate cytokines, the purpose of this study was to evaluate the influence of AO supplements on cytokines pre‐ and post‐ACL surgery. A randomized, double‐blind, placebo‐controlled study was conducted in men undergoing ACL surgery, who were supplemented with AO or placebos (PL; n = 10/group). Supplementation began ~2‐w prior to and concluded 3‐mo after surgery. Fasting plasma AO and cytokines were measured. IL‐6, IL‐10, and IL‐2rα increased (P < 0.05) and PGF2α decreased (P < 0.05) following ACL surgery and during NSAID medication. AO supplementation ameliorated (P < 0.05) the increase in IL‐10. Thus, despite standard of care NSAID medication, a systemic cytokine response occurred post‐surgery, and AO protected against the increase in IL‐10. By 3‐mo post‐surgery and after the discontinuation of NSAIDs, IL‐1β increased (P < 0.05), but for a given increase in IL‐1β, AO potentiated the increase (P < 0.05) in IL‐4. The AO potentiated increase in IL‐4 may limit the systemic release of IL‐1β and protect against the adverse sequelae of inflammatory responses. In conclusion, AO supplementation induced immunological alterations after ACL surgery indicative of a better prognosis. Source of support: USANA Health Sciences, Inc., SLC, UT.