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Modulatory effects of Emblica officinalis (Amla) on adipocytokines in mice fed high‐fat‐diet (HFD)
Author(s) -
Kipyakwai Gideon Kipkoech,
Buesa Lance Martinez,
Nerurkar Pratibha V.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.528.3
Subject(s) - leptin , resistin , adipokine , emblica officinalis , medicine , obesity , endocrinology , overnutrition , diabetes mellitus , traditional medicine
Overnutrition is correlated with obesity and associated metabolic disorders including type 2 diabetes (T2D) and cardiovascular diseases. Studies indicate that adipocytokine leptin is a key element in regulating food intake and obesity. Plasma levels of leptin are also known to inversely correlate with body fat mass. The objective of our study was to investigate the effects of Ayurvedic medicine Emblica officinalis (amla, EO) on adipocytokine regulation in mice fed 58% kcal high‐fat‐diet (HFD) for 16 weeks. Male C57BL/6J mice were randomized into four groups: 1) control, 2) EO (10% w/w), 3) HFD and 4) HFD + EO. After 16 weeks, EO had no significant effect on daily food intake but improved body weights and plasma levels of leptin and resistin. We are currently investigating the effects of EO on leptin and resistin signaling in adipocytes. Such studies offer mechanistic evaluations for potential use of alternative medicine. [Grants: NCCAM (R21AT003719), USDA‐CREES (2004‐34135‐15182)].