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Endocytic nanodiamond for the labeling and tracking of cancer cells
Author(s) -
Chao JuiI,
Liu KuangKai
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.525.1
Subject(s) - nanodiamond , endocytic cycle , pinocytosis , endocytosis , microbiology and biotechnology , cancer cell , cytoplasm , cell division , cell , chemistry , cell culture , cancer , nanotechnology , biology , materials science , biochemistry , genetics , organic chemistry , diamond
Nanodiamond (ND) is carbon nanomaterial developing for biological applications. We found that ND particles were taken into cells by macropinocytosis and clathrin‐mediated endocytosis pathways. ND particles were equal separating into two daughter cells of cell division approximately. Finally, the cell retained a single ND cluster in cytoplasm after sub‐cultured for several generations. Interestingly, ND clusters were carried inside of cell but without inducing damages after long‐term cell culture. Together, these findings provide that endocytic ND particles are non‐cytotoxic in cell division, which can be applied for the labeling and tracking of cancer cells.