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Molecular Mechanism of Nanodiamonds Attacking Cancer Cell
Author(s) -
Chen HongWei,
Cheng TsaiMu,
Chu HsuehLiang,
Chang ChiaChing
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.520.1
Subject(s) - nanodiamond , graphite , diamond , molecule , conjugated system , fluorescence , materials science , nanotechnology , growth hormone receptor , chemistry , chemical engineering , optics , organic chemistry , growth hormone , hormone , biochemistry , physics , polymer , engineering
Nanodiamond (ND) surrounds with layers of graphite on its surface. This unique structure feature creates unusual fluorescence spectra which can be used as an indicator to monitor its surface modification. Meanwhile, it contains nitrosol (C‐N=O) inside the ND and this impurity can absorb nanosecond laser radiation to cleavage the ‐C‐N=O chemical functional group into ‐C +N≡O. Moreover, the NO gas molecules are heated by hot phonon of ND and generate huge pressure inside the diamond core to facilitate the sp3 diamond core transforming into sp2 graphite structure as a nanoblast. Therefore, the growth hormone receptor (GHR) of cell surface can be destroyed by growth hormone conjugated‐ND (NDGH) and then be triggered the process of cell apoptosis. This photo‐trigger nanoblast can be used as nano‐knifes in nano‐medicine application.