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Adipose tissue responses to binge and restrictive eating in ground squirrels
Author(s) -
Kohlnhofer Bridget M,
Cooper Scott T,
Maher Margaret A
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.502.2
Subject(s) - ground squirrel , adiponectin , leptin , endocrinology , medicine , adipose tissue , hibernation (computing) , resistin , biology , overeating , hormone , adipocyte , appetite , obesity , insulin resistance , state (computer science) , algorithm , computer science , thermoregulation
Fat cells provide peripheral feedback to the brain for appetite regulation. Adiponectin, leptin, and resistin are adipocyte hormones and PPARs are diet (fatty acid) sensitive transcription factors that modulate glucose and fatty acid metabolism. The 13‐lined ground squirrel (Spermophilus tridecemlineatus) is a natural model of binge and restrictive eating associated with hibernation and coincident alterations in metabolism. We have compared key regulators of metabolism and appetite, in adipose tissue from non‐hibernating versus hibernating ground squirrels, with quantitative PCR. Amplification crossing points were determined for each gene and normalized to that of actin. Preliminary studies revealed adiponectin and PPAR alpha transcription were up‐regulated 6 and 16‐fold, respectively, while PPAR gamma transcription was down‐regulated by 3‐fold during hibernation. Adiponectin results are consistent with observations by others that levels of this hormone are inversely related to fat mass, which would be predicted to decline during hibernation. Future studies will address dietary versus endogenous nutrient contributions to these observations. Funded by University of Wisconsin‐System and WiSys grants.