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Effect of Fucus evanescens Fucoidan on Expression of Matrix Metalloproteinase‐1 Promoter, mRNA, Protein and Signal Pathway
Author(s) -
Lee Yong Hwan,
Ku Mi Jung
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.484.3
Subject(s) - fucoidan , hacat , fucus vesiculosus , mapk/erk pathway , matrix metalloproteinase , messenger rna , fucus , chemistry , extracellular matrix , microbiology and biotechnology , biology , biochemistry , in vitro , signal transduction , polysaccharide , gene , algae , botany
Fucoidan, a sulfated polysaccharide from the brown algae Fucus evanescens belong to the order Fucales . There are no studies which report effects of F. evanescens fucoidan on skin. In this study, we assessed the effects of F. evanescens fucoidan on UVB‐induced MMP‐1 protein, mRNA, promoter and phosphorylation of MAPKs activities in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP‐1 protein, mRNA, promoter activity in a dose‐dependent manner compared to the control. We also found that fucoidan markedly reduced the UVB‐induced activation of ERK. We suggest that F. evanescens fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.