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VEGF up‐regulates pro‐inflammatory factors in the cervix of mice
Author(s) -
Schwabe John,
Boggess Bethany,
Nguyen BaoTran,
Gosai Puja G.,
Tashakkori Parisa,
Mowa de K,
Mowa Chishimba N
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.453.4
Subject(s) - inflammation , vegf receptors , cervix , vascular endothelial growth factor , lipopolysaccharide , medicine , receptor , cancer research , immunology , cancer
Cervical remodeling (CR) entails a physiological inflammatory response that can be induced by inflammatory agents, such as lipopolysaccharide (LPS), and inflammation is closely associated with vascular remodeling. Recently, we showed that LPS‐induced inflammation up‐regulates mRNA levels of vascular endothelial growth factor (VEGF) and its receptors, KDR and Flt‐1. Here, we sought to investigate whether VEGF can modulate inflammation by characterizing the expression pattern of pro‐inflammatory factors in VEGF‐treated mice using real time PCR. Our data revealed that VEGF up‐regulates a group of pro‐inflammatory factors in the cervix, including IL‐6. Collectively, our studies show a possible existence of a positive feed forward loop between inflammatory and vascular factors in the remodeling cervix. Grant Funding Source : Appalachian State University