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A detailed anatomical study of the papillary muscles and chordae tendineae of the left ventricle in perfusion fixed human hearts
Author(s) -
Bateman Michael Geoffrey,
Russell Cori E,
Chan Brian Y,
Iaizzo Paul A
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.446.4
Subject(s) - chordae tendineae , ventricle , papillary muscle , anatomy , medicine , perfusion , diastole , cardiology , mitral valve , blood pressure
Classical cardiac terminology describes the existence of two papillary muscles in the left ventricle; the anterolateral and the posteromedial. However, individual hearts can display multiple papillary muscles in either region and cardiac pathologies can greatly alter their sizes and shapes. Perfusion fixed human hearts (n=75) are employed for this study due to the unique attributes of their preservation whereby 10% formalin is continuously pumped into the great vessels fixing each heart in an end diastolic state. Endocscopic video footage and MRI stacks have been used to establish the position and size of the papillary muscles relative to the septal wall. Following this a smaller sample size will be dissected and the anatomical features of the papillary muscles and chordae will be recorded. To date, we have observed only a fraction of hearts in the library that elicit the classically defined anatomy and believe that an appropriate terminology can be used to greatly benefit the design and development of left sided trans‐catheter delivered systems and devices. Support for this project has been provided by the Dept. of Surgery and the IEM at the University of Minnesota.