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The Design Logic of Cell Signaling Systems
Author(s) -
Lim Wendell A
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.410.2
Subject(s) - modular design , set (abstract data type) , synthetic biology , systems biology , simple (philosophy) , computer science , computational biology , biology , programming language , philosophy , epistemology
Cells use complex networks of signaling proteins to accurately transmit information and make decisions. Despite their complexity, many of these systems appear to be built from a finite set of relatively simple modular catalytic and regulatory components. We are studying the logic of how such modules are used to build complex signaling systems. We are tracking how signaling modules originated and how they are used as building blocks in evolution. We are also exploring how these modules can be used in synthetic biology to engineer cells with new behaviors and potential therapeutic or biotechnological applications.