Premium
Expression Profiles of Metastasis‐Related Genes in a Cohort of Childhood and Adult Adrenocortical Tumors
Author(s) -
Lin Chin Jia,
Lerario Antonio Marcondes,
Fragoso Maria Candida,
Mendonca Berenice Bilharinho
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.354.2
Subject(s) - metastasis , adrenocortical carcinoma , gene , carcinogenesis , cancer research , biology , pathology , oncology , medicine , cancer , genetics
Backgroud Adrenocortical carcinoma (ACC) is a rare neoplasm with a poor prognosis. Although molecular studies have uncovered many aspects of ACC tumorigenesis, little is known about molecular pathways involved in metastatic spread. The objective of our study is to analyze the expression profile of metastasis‐related genes in a cohort of metastatic and non‐metastatic adrenocortical tumors in order to identify genes involved in the metastatic spread. Methods The expression profiles of 27 adrenocortical tumors from 15 adults (8 ACC and 7 adenomas) and from 12 children (5 metastatic and 7 non‐metastatic) were evaluated by an array of 113 genes known to be involved in human metastasis. Results The comparison of adult adenoma and ACC identified 13 differentially expressed genes. In the pediatric group, 6 genes were found to be differentially expressed between metastatic and non‐metastatic tumors. Most of the differentially expressed genes are involved in processes of cell cycle control and extracellular matrix remodeling. Conclusion the expression profiles of metastasis‐relatad genes identified important aspects of involved in metastatic spread of adrenocortical tumors. Distinctive patterns of gene expression between metastatic and non‐metastatic tumors may be useful in prognosis prediction.