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A Mediterranean‐style low glycemic diet decreases inflammation and insulin resistance in subjects classified with the metabolic syndrome
Author(s) -
Andersen Catherine Julia,
Jones Jennifer,
Barona Jacqueline,
Calle Mariana,
Lerman Robert H,
McIntosh Mark,
Kalynych Colleen,
Vukich Claire,
Volek Jeff S,
Fernandez Maria Luz
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.342.2
Subject(s) - medicine , adiponectin , endocrinology , insulin resistance , glycemic load , glycemic , leptin , adipokine , metabolic syndrome , insulin , waist , glycemic index , obesity
Women classified with metabolic syndrome (MS) adhered to a low glycemic diet alone (n = 40) or accompanied by intake of a medical food containing plant sterols, soy protein (PSS), rho iso‐alpha acids, and proanthocyanidins from acacia (n = 44). All women decrreased energy intake (p < 0.00001) after 12 wk. The intake of fat was reduced by 42 % (P < 0.0001), carbohydrate by 38.5% (P < 0.0001), while protein was increased by 13.6%, with the PSS group consuming higher levels of vegetable protein (P < 0.05). Glycemic load was also decreased from 128.5 to 48.2. The adipokines, leptin (P < 0.0001) and tumor necrosis factor alpha (TNF‐α) (P< 0.0005) significantly decreased over time. Waist circumference (WC) decreased for all women (P < 0.0001) and these reductions were strongly correlated with decreases in leptin (r = 0.316, P < 0.05). Interestingly, protein intake was negatively correlated with plasma concentrations of TNF‐α (r= −0.319, P < 0.05). Decreases in interleukin‐6 were correlated with decreased energy intake (r = 0.305, P < 0.05) while the reductions in fat (r = 0.380, P < 0.01) and glycemic load (r = 0.386, P < 0.01) were correlated with decreases in insulin. In contrast, changes in adiponectin were negatively correlated with energy (P < 0.001) and carbohydrate intake (P < 0.05). These data suggests that energy reduction and high vegetable protein, in combination with weight loss improves the chronic inflammatory state in subjects with MetS. [Supported by MetaProteomics, LLC, Gig Harbor, WA]