Premium
CLINICAL EFFICACY OF PROBIOTIC STRAINS AND THEIR APPLICATION FOR DEVELOPMENT
Author(s) -
Ji Geun Eog
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.340.7
Subject(s) - bifidobacterium bifidum , probiotic , ginseng , lactobacillus casei , irritable bowel syndrome , lactobacillus acidophilus , bifidobacterium , lactobacillus , medicine , traditional medicine , biology , microbiology and biotechnology , food science , fermentation , bacteria , genetics , alternative medicine , pathology
Probiotic strains such as B. bifidum BGN4, B. lactis AD011, Lactobacillus acidophilus AD031, and L. casei IBS041 were developed through the series of in vitro and animal experiments. Double‐blind, randomized placebo‐controlled human trials with combinatory probiotic strains including Bifidobacterium and Lactobacillus significantly lowered the prevalence of atopic dermatitis in infants and the pain scores in irritable bowel syndrome patients. Recently, the application of lactic acid bacteria for the transformation of ginsenosides has drawn considerable interests because of their potential to enhance the biological activities of ginseng. Ginsenosides have been regarded as the principal components responsible for pharmacological and biological activities of ginseng. After transformation, major ginsenosides comprised of compound K, Rh1, and Rh2. Fermented ginseng (FG) showed greater effect than unfermented ginseng in the suppression of ovalbumin‐induced allergy. The FG also lowered blood glucose level in the DB/DB mice model. In conclusion, selected probiotic strains were shown to exert clinical efficacies and enhance the biological activities of ginseng.