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Glycemic index does not affect overall glucagon like peptide – 1 levels in healthy overweight women
Author(s) -
Casey Shavawn Marie,
Horn William,
Hembrooke Tara,
Keim Nancy
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.330.6
Subject(s) - postprandial , meal , incretin , glycemic index , overweight , medicine , glucagon like peptide 1 , glycemic , ingestion , gastric emptying , glucagon , endocrinology , insulin , body mass index , diabetes mellitus , type 2 diabetes , stomach
Background Glucagon‐like peptide‐1 (GLP‐1) is secreted in response to food ingestion specifically carbohydrate‐rich food sources. GLP‐1 is involved in a variety of physiologic functions including: regulation of plasma glucose, inhibition of gastric emptying, and decreasing food intake by increasing satiety. Methods A randomized cross‐over design was used to measure the incretin response to 2 standardized breakfast meals: a high glycemic index (HGI) meal and a low glycemic index (LGI) meal. Both meals were matched for energy and macronutrient contents (54% C, 15% P, & 31% F). Seven healthy, overweight women participated. Blood samples were obtained before and for 8 hours following consumption of the test meals. Plasma GLP‐1 [(7–36) and (7–37) amide] quantification was done by active ELISA assay. Results There were no differences in fasting plasma GLP‐1 or in postprandial GLP‐1 in response to the HGI and LGI breakfast meals. Grant Funding Source: general funds and the USDA, ARS WHNRC Grant Funding Source : USDA