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Cranberry phytochemicals modify human immune function and appear to reduce the severity of cold and flu symptoms
Author(s) -
Nantz Meri P.,
Rowe Cheryl A.,
Muller Catherine E.,
Creasy Rebecca,
Chapkin Chelsea,
Pasqualini Sofia,
Lozada Jillian,
Khoo Christina,
Percival Susan S.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.326.6
Subject(s) - immune system , proanthocyanidin , placebo , in vivo , polyphenol , cranberry juice , ex vivo , pharmacology , immunology , biology , food science , chemistry , medicine , traditional medicine , antioxidant , biochemistry , microbiology and biotechnology , pathology , alternative medicine , urinary system
Proanthocyanidins (PACs) are complex molecules that have been suggested to have health benefits, most recently in relation to immune function. Cranberries are an excellent source of PACs, possessing both the A‐ and B‐type linkages, and in addition, contain other polyphenols. We hypothesized that the PAC contained in cranberries could modify specific human immune cells in vivo, particularly the γδ T cell which is known to recognize and respond to PACs in vitro. This effect is thought to be related to non‐microbial priming of the immune cells by the phytochemicals. In a randomized, double‐blind, placebo‐controlled human study, 10 weeks of consumption of a beverage containing a powder derived from cranberries resulted in a fivefold increase in proliferation of γδ T cells ex vivo, a 30% increase in NK cell proliferation and a 20% reduction in IL‐17 secretion. Subjects consuming the beverage made with cranberry powder had fewer cold and flu symptoms (p=0.010) when compared to those consuming the placebo. The incidence of illnesses, total missed work days, and decrease in activities tended to be lower, however actual values were not significantly different from placebo. Consumption of cranberry phytochemicals was shown to modify certain aspects of immune function, suggesting that consuming cranberries may help support immune health. Supported by Ocean Spray Cranberries, Inc and FAES