Premium
Effects of alcohol and alcohol‐metabolizing SNPs on serum vitamin D levels in postmenopausal women in a controlled feeding study
Author(s) -
Mahabir Somdat,
Baer David,
Pfeiffer Ruth,
Taylor Philip R.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.325.7
Subject(s) - alcohol , cyp2e1 , crossover study , placebo , medicine , ethanol , vitamin , alcohol consumption , aldh2 , endocrinology , vitamin d and neurology , chemistry , biochemistry , metabolism , genotype , cytochrome p450 , alternative medicine , pathology , gene
Background Among alcoholics vitamin D metabolism is altered and alcoholics have decreased vitamin D levels. However, no published data is available on the role of low to moderate alcohol consumption on vitamin D levels. Objective The objective of this study was to evaluate the effects of 8 weeks of no alcohol, low (1 drink or 15g/d) and moderate (2 drinks or 30g/d) alcohol consumption on serum 25(OH)D concentrations in postmenopausal women in a controlled feeding study and to assess whether alcohol metabolizing SNPs (ADH1B_02, ADH1B_05, ADH1C_01, ADH1C_02, ALDH2_07, CYP2E1_02, CYPE2_06, CYP2E1_07, CYP2E1_12, CYP2E1_13, CYP2E1_21, CYP2E1_22) modified the levels of 25(OH)D. Design Postmenopausal women (n = 51) consumed 0, 1 drink, and 2 drinks of alcohol/day for 8 weeks as part of a controlled diet in a randomized crossover design. Fasting blood samples were drawn at baseline, at 4 weeks and at 8 weeks. Serum 25(OH)D concentrations were measured by ELISA. Wilcoxon rank sum and linear mixed models were used to compare differences in serum 25(OH)D concentrations from placebo to 1 and 2 drinks/day in the 8‐week samples. Results 1 or 2 drinks/day for 8 weeks had no significant impact on serum 25(OH)D concentrations. We did not find any significant interactions between any of the SNPs and alcohol treatment on serum 25(OH)D concentrations. Conclusion The data indicate that low to moderate alcohol consumption for 8 weeks had no significant impact on serum 25(OH)D concentrations among postmenopausal women in a tightly controlled feeding study.