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The relationship of serum 25‐hydroxyvitamin D and parathyroid hormone from pooled data in children and adolescents
Author(s) -
Hill Kathleen M,
McCabe George P,
McCabe Linda D,
Gordon Catherine M,
Abrams Steven A,
Weaver Connie M
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.325.5
Subject(s) - parathyroid hormone , vitamin d and neurology , medicine , endocrinology , inflection point , hormone , vitamin d deficiency , chemistry , calcium , mathematics , geometry
Serum 25‐hydroxyvitamin D (25(OH)D) is the primary indicator of vitamin D status. In adults, maximal suppression of serum parathyroid hormone (PTH) has been used to determine sufficiency for serum 25(OH)D. In children and adolescents, however, the relationship between serum 25(OH)D and PTH is less clear and the normal range for PTH is not well established. We pooled data from 735 children and adolescents (7–18 y, 30% male) studied at 3 different geographical sites to investigate the relationship between serum 25(OH)D and PTH. Using a spline approach, the point of inflection for PTH suppression is 25(OH)D = 39.4, 95% CI 25.99, 53.0 ng/mL. The average 25(OH)D is 26.6±10.3 ng/mL. When high PTH (>100 pg/mL) values are excluded, no point of inflection for PTH suppression is evident. As serum 25(OH)D has not been associated with improved Ca absorption or retention in children and adolescents and PTH has been positively associated with Ca absorption in adolescents, we infer that the inflection point for suppression of PTH around the average serum 25(OH)D indicates this is inappropriate as a basis for determining optimal 25(OH)D for this age group.Grant Funding Source: NIH 1R01HD061908‐01A2