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Fatty acid intake and bone mineral density, structure and strength; measured by pQCT in young girls
Author(s) -
Laudermilk Monica Janeene,
Going Scott B,
Thomson Cynthia A,
Houtkooper Linda
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.324.6
Subject(s) - quantitative computed tomography , bone mineral , tibia , femur , cortical bone , medicine , endocrinology , bone density , polyunsaturated fat , osteoporosis , anatomy , saturated fat , surgery , cholesterol
Background Diet may influence maximum growth rates and accrual of BMD during pre‐adolescence. In vivo , in vitro and human studies linking fat intake and bone status reveal biphasic effects dependent on fatty acid quantity and composition. Objective To assess the relationship of fatty acid intake and bone parameters in young girls. Design Cross‐sectional study of 363 girls age 8–12 y. Methods Girls completed the Harvard Youth/Adolescent Food Frequency Questionnaire. Bone parameters were measured by peripheral quantitative computed tomography (pQCT) in the non‐dominant leg. Results 4 th grade: Fat intake was a negative correlate of periosteal circumference, trabecular and cortical area, and bone strength. Polyunsaturated fat and ω6 were positive correlates of femur cortical density. Monounsaturated fat was a positive predictor of tibia trabecular area. 6 th grade: ω6:ω3 intake was inversely associated with tibia trabecular and cortical area and periosteal circumference. ω6:ω3 was a negative correlate and predictor of femoral bone strength. Total fat, saturated fat, ω3 and ω6:ω3 predicted cortical densities, trabecular area, endosteal and periosteal circumferences of the tibia and femur. Conclusion Cross‐sectional fat intake is related to bone status measured by pQCT and can have a type dependent, regio‐specific impact that may vary through maturation. The Jump‐In study was funded by NIH: HD050775.Grant Funding Source: NIH: HD050775