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Effects of polyunsaturated n‐3 fatty acids in the prevention of metabolic syndrome in golden syrian hamster fed with high fat diet
Author(s) -
Fatima Kasbi Chadli,
Kadiatou Soumah,
Thierry Magot,
Patrick Nguyen,
Ouguerram Khadija
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.323.7
Subject(s) - dyslipidemia , polyunsaturated fatty acid , medicine , endocrinology , hypertriglyceridemia , metabolic syndrome , insulin resistance , chemistry , obesity , postprandial , cholesterol , insulin , triglyceride , fatty acid , biochemistry
High fat diets are among majors factor for the predisposition to metabolic syndrome including obesity, insulin resistance, dyslipidemia, and cardiovascular diseases. Previous studies have demonstrated the effects of ω3 polyunsaturated fatty acids (PUFA) on dyslipidemia. In our study we investigated the preventive effect of this fatty acid in western diet (45% of total energy intake) enriched (HFDω3) or not (HFD) in ω3 PUFA (EPA and DHA) at ω6/ω3=3 ratio on different parameters: the lipids status (plasma TG, total cholesterol, and HDL cholesterol), the insulin sensitivity, and the body composition. The results indicate that PUFA ω3 had no effect on food consumption but tended to lower body fat percentage (HFD:17.6±4 %; HFDω3: 13.9±6; p=0.09), prevented weight gain (HFD:124±7g; HFDω3:111±6g; p=0.02), and limited hypertriglyceridemia (HFD: 2.03±0.3g/L; HFDω3: 1.41±0.2g/L; p=0.01) and postprandial TG (HFD: 2.65±0.7g/L; HFDω3: 1.58±0.5g/L; p=0.04) This reduction resulted from lower that was reduced by 60% 4 hours after injection of triton (HFD: 7.93 ± 1.61g/L; HFDω3: 4.19 ± 0.88g/L; p=0.01). HFD enriched on ω3 PUFA have also positive effect on insulin sensitivity (HOMA Matthews p=0.04). We conclude that ω3 PUFA have protective effect against obesity and dyslipidemia in golden Syrian hamster fed with high fat diet.