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Omega‐3 Fatty‐Acid Intake in Relation to Serum Lipid Concentrations in African‐Americans: Jackson Heart Study (JHS)
Author(s) -
Landry Latrice Goosby,
Taylor Herman A.,
Carithers Teresa,
Lichtenstein Alice H.,
Tucker Katherine L.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.323.3
Subject(s) - triglyceride , eicosapentaenoic acid , medicine , blood lipids , endocrinology , population , high density lipoprotein , cholesterol , docosahexaenoic acid , fatty acid , chemistry , polyunsaturated fatty acid , biochemistry , environmental health
Diets high in ω‐3 fatty‐acids (FA) are associated with healthier lipid profiles. This study examines the relationship between ω‐3 FA intake and serum lipids in a cohort of African‐Americans. Using SAS 9.1, we calculated mean intake of total ω‐3 FA, α‐linolenic (ALA), eicosapentaenoic (EPA), and docasahexaenoic (DHA) from a FFQ. We examined the association between percent of energy from ω‐3 FA(s) with high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG) concentrations. Multiple regression adjusting for age, sex, and BMI was done including 4,771 members of JHS. Average intake of DHA+EPA was <0.5g/day and intake of ALA averaged 1.5g/day. Omega‐3 FA intake was not associated with LDL concentration. Percent ALA showed a marginally positive association with HDL cholesterol (p=0.06). A strong negative association was found between ALA (p=0.006) and TG concentration. No significant associations were found with DHA and EPA and serum lipids. The data show strong negative associations between ALA and ω‐3 with TG and a weaker positive association with HDL. Consistent with the literature, TGs were the most affected by ω‐3 intake. Clinical implications of this research should focus on increasing ω‐3 intake in this population to improve lipid profiles. Due to data limitations, supplemental intake of FA or lipid lowering medications were not controlled which could affect the results. Grant Funding Source: N01HC95170