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Sweet Packets: What Glycomics can tell us about Viruses and Microvesicles.
Author(s) -
Mahal Lara K.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.298.3
Subject(s) - microvesicles , glycomics , biogenesis , microbiology and biotechnology , glycan , glycoprotein , cell , biology , chemistry , computational biology , biochemistry , microrna , gene
Glycans, which coat the cell surface, are involved in the sorting of both proteins and lipids to membrane microdomains, thus they can act as molecular markers for trafficking pathways. Some viruses including HIV‐1, as well as membrane‐bound nanoparticles known as microvesicles are thought to derive from microdomains on the cell surface. A recent advance in glycomic technology, lectin microarrays, has made possible the rapid analysis of the carbohydrate composition of complex biological samples. Herein, we use this technology to study the glycomes of viruses, microvesicles and the host membranes of cell lines from they derive to gain biological insights into the composition and biogenesis of these particles.