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A single dose of quercetin lowers blood pressure in hypertensive but not prehypertensive males
Author(s) -
Larson Abigail,
Guo Yi,
Black Kathryn S,
Hayman Melissa A,
Richardson Russell S,
Bruno Richard S,
Jalili Thunder,
Symons J David
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.230.6
Subject(s) - prehypertension , blood pressure , medicine , endocrinology , heart rate , placebo , quercetin , chemistry , antioxidant , biochemistry , alternative medicine , pathology
Previously we reported that 730 mg/d quercetin (Q) for 28 d reduces blood pressure (BP) in hypertensive subjects without affecting systemic markers of oxidative stress. Q supplementation in hypertensive rodents lowers BP by decreasing ACE activity. We hypothesized that a single dose of Q would lower BP and ACE activity in hypertensive males. A preliminary study conducted in normotensive males (n=6) indicated that maximal plasma Q concentrations (2.33 ± 0.72 μM) occurred 10 h after ingesting 1095 mg Q and levels returned to baseline (0.45 ± 0.06 μM) by 24 h. Based on these data hypertensive (n = 6, 40 ± 11 y, BMI < 35) and prehypertensive (n = 5, 48 ± 10 y, BMI < 35) males consumed a low Q diet for 7 days. Participants then ingested placebo (P) or 1095 mg Q, with each treatment separated by >48 h. BP (mmHg), heart rate (HR), and blood samples to assess ACE activity (U/L) were obtained 10 h later after an overnight fast. In hypertensive males systolic BP (139 ± 3 vs. 149 ± 3) and mean BP (105 ± 3 vs. 112 ± 3) were decreased (p<0.05) by Q vs. P treatment, respectively. ACE activity was not different between the Q (16 ± 4 U/L) and P (18 ± 4 U/L) treatments. BP, HR, and ACE activity were similar 10 h following Q and P in prehypertensive subjects. Thus, a single Q dose decreases BP in hypertensive but not prehypertensive males. Grant Funding Source: PEAK Academy of the University of Utah