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Maternal Vitamin D Status and Child Tuberculosis, Anemia, and Morbidity in Tanzania
Author(s) -
Finkelstein Julia L,
Mehta Saurabh,
Manji Karim P.,
Duggan Christopher P.,
Mugusi Ferdinand M.,
Spiegelman Donna,
Msamanga Gernard I.,
Fawzi Wafaie W.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.227.3
Subject(s) - medicine , vitamin d and neurology , anemia , tuberculosis , microcytosis , vitamin d deficiency , pediatrics , diarrhea , iron deficiency , pathology
Objective To examine the association of maternal vitamin D status with child health outcomes. Methods Vitamin D status [serum 25(OH)D] was determined in 884 HIV‐infected pregnant Tanzanian women at enrolment in a trial of vitamins. Children born to these women were followed‐up until 24 months of age and morbidity was recorded. Tuberculosis (TB) was diagnosed via chart review. Proportional hazards models were used to assess the associations of outcomes with maternal vitamin D status. Results Children born to women with low vitamin D (<32ng/mL) levels were 1.58 times more likely to develop pulmonary TB (95%CI: 1.01–2.47), after adjusting for age, HIV stage, CD4 count, and regimen. Low vitamin D status was associated with 1.21 times greater risk of cough (95%CI: 1.05–1.40). No significant associations were noted for diarrhea or other respiratory symptoms. For anemia outcomes, no association was observed with low vitamin D status. However, in quintile analyses, children born to women in the second quintile had lower risk of severe anemia (Hb<8.5g/dL) (RR: 0.64; 95%CI: 0.45–0.92) and severe hypochromic microcytosis (RR: 0.34; 95%CI: 0.16–0.71), compared to the lowest quintile. Conclusion Vitamin D status may affect risk of child outcomes, such as tuberculosis and anemia. Further research is warranted to examine the role of optimizing vitamin D status in reducing morbidities in children born to HIV‐infected women. Grant Funding Source: NICHD R01 32257