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Pharmacokinetics of flavonoids and phenolic acids from cranberry juice cocktail in humans
Author(s) -
McKay Diane L.,
Chen ChungYen Oliver,
Blumberg Jeffrey B
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.209.1
Subject(s) - bioavailability , cmax , chemistry , cranberry juice , protocatechuic acid , pharmacokinetics , polyphenol , food science , gallic acid , pharmacology , medicine , urinary system , biochemistry , antioxidant
Putative health benefits attributed to cranberry consumption include a reduced risk of urinary tract infections, stomach ulcers, and cardiovascular disease. However, data on the bioavailability and metabolism of cranberry bioactives, including flavonoids and phenolic acids, are required to better understand their impact on pertinent risk factors for chronic disease, and inform the design of relevant clinical trials. We conducted a single‐dose, pharmacokinetic study to characterize the bioavailability of cranberry flavonoids and phenolics acids from cranberry juice cocktail (CJC) in 10 healthy adults with BMI 18.5–29.9, and age 50–70 y. After a 2‐d run‐in period following a low polyphenol diet, fasted subjects consumed 237 mL low‐calorie, sugar‐free CJC (54% juice). Blood samples were collected at specified time points before and up to 24 h after beverage consumption. We found marked variation in the maximal plasma concentration (Cmax) and time to reach Cmax (Tmax) of these cranberry bioactives, e.g., sinapic acid with 18.6 ng/mL at 30 min, homovanillic acid with 54.1 ng/mL at 6 h, protocatechuic acid with 1.3 μg/mL at 10 h, myricetin with 18.3 ng/mL at 2 h, quercetin with 0.4 μg/mL at 8 h, and kaempferol with 18.4 ng/mL at 2 h, respectively. These data suggest that different phenolic constituents in CJC are absorbed and metabolized at different locations in the gastrointestinal tract. (Supported by USDA and Ocean Spray, Inc.)