Premium
Maternal and Neonatal Iron Status Impact the Expression of the Heme Transporter, FLVCR, in the Placenta
Author(s) -
Jaacks Lindsay Marie,
Young Melissa F.,
Essley Bridget V.,
McNanley Thomas J.,
Cooper Elizabeth M.,
Pressman Eva K.,
Mcintyre Allison W.,
Orlando Mark S.,
Abkowitz Janis L.,
Guillet Ronnie,
O'Brien Kimberly O.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.208.6
Subject(s) - placenta , transferrin receptor , andrology , hemoglobin , ferritin , iron status , umbilical cord , heme , gestation , pregnancy , soluble transferrin receptor , medicine , chemistry , transferrin , endocrinology , fetus , biology , immunology , iron deficiency , anemia , biochemistry , enzyme , genetics
Mechanisms of placental heme iron transport are largely unknown. To address this, expression of the heme transporter Feline Leukemia Virus, Subgroup C, Receptor (FLVCR) was measured in placental tissue from 84 pregnant teens (13–18 y). Iron (Fe) status indicators, serum ferritin (SF) and serum transferrin receptor (sTfR), were measured at mid‐gestation (25.1±3.5 wks) and in maternal/cord blood at delivery (39.8±1.1 wks). At delivery, 33% (18/54) of teens were anemic (Hb<11 g/dL); hemoglobin (Hb) averaged 11.6±1.5 g/dL (n=54). Maternal SF at delivery was 21.8±13.3 μg/L (n=67); 52% (35/67) had depleted Fe stores (SF<20 μg/L). Neonatal SF averaged 140.8±79.9 μg/L (n=65). At delivery, maternal and neonatal sTfR averaged 5.8±3.7 mg/L (n=66) and 8.0±2.4 mg/L (n=65), respectively. A significant relationship was observed between maternal mid‐gestation SF and neonatal SF (p<0.05, n=52) and between placental FLVCR expression and the maternal delivery: neonatal SF ratio (p<0.01, n=43). Although FLVCR expression was regulated in response to maternal and neonatal Fe status, up‐regulation of this protein was not sufficient to normalize ferritin stores in neonates born to teens with depleted Fe stores. Funded by: NRI Grants 2008‐01857 & 2005‐35200, USDA HATCH (2006‐07‐160), and HHMI.