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New roles for sirtuins in mitochondrial metabolism
Author(s) -
Haigis Marcia
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.198.2
Subject(s) - nad+ kinase , yeast , metabolism , biochemistry , sirt3 , mitochondrion , biology , saccharomyces cerevisiae , enzyme , fatty acid metabolism , microbiology and biotechnology , chemistry , sirtuin
Sir2 is an NAD‐dependent deacetylase that connects metabolism with longevity in yeast, flies, and worms. Mammals contain seven homologs of yeast Sir2. Previously we showed that SIRT4, a mammalian Sir2 homolog, is a mitochondrial enzyme that ADP‐ribosylates and down‐regulates glutamate dehydrogenase (GDH), thereby enhancing insulin secretion in the pancreas. Here we show that SIRT4 functions to down‐regulate fatty acid oxidation in the liver. We will discuss implications for SIRT4 function in obesity and age‐related diseases. We will also discuss the coordination of sirtuins in the control of metabolism.