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Wnt Target Genes in CNS Development
Author(s) -
Dorsky Richard Ian
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.177.1
Subject(s) - wnt signaling pathway , zebrafish , progenitor cell , biology , psychological repression , neural stem cell , microbiology and biotechnology , progenitor , central nervous system , stem cell , function (biology) , regeneration (biology) , signal transduction , gene , neuroscience , genetics , gene expression
We are interested in the function of Wnt signaling and Lef/Tcf factors in the developing zebrafish central nervous system. In the spinal cord we have evidence that Tcf3 acts to maintain the multipotent progenitor state, both through direct transcriptional regulation and through a novel post‐transcriptional pathway. In the hypothalamus we have identified a role for Tcf7 and Lef1 as Wnt‐mediated activators regulating the development and maintenance of committed neural precursors. We have also identified Lef/Tcf target genes in both processes. Together our data fit with established roles for Lef/Tcf factors in other epithelial tissues, where Tcf3‐mediated repression acts to maintain the stem cell state, while Wnt‐mediated activation supports the progression of cells into a differentiation pathway.