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A transmurally and regionally heterogeneous fully coupled computational electro‐mechanics model of the canine left ventricle
Author(s) -
AguadoSierra Jazmin,
Campbell Stuart G,
Howard Elliot,
Omens Jeff H,
McCulloch Andrew D,
Kerckhoffs Roy CP
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1060.5
Subject(s) - ventricle , myofilament , mechanics , cardiology , medicine , chemistry , physics , myocyte
The cardiac cell structure and function is heterogeneous. These heterogeneities are finely orchestrated to optimize the whole organ function in health. A computational model is used to analyze the stress, strain and haemodynamic effects of including a transmurally (endo, mid and epi) and regionally (apex to base) heterogeneous substrate to a fully coupled model of electromechanics in an idealized ventricular geometry. Campbell et al. (2009) developed a canine myocyte ionic current and cytosolic Ca 2+ cycling model that was integrated to a myofilament model. This mathematical model was embedded element‐wise into a finite element mesh of an idealized geometry with fiber angles and haemodynamic boundary conditions to understand the effects of cell heterogeneity on systolic fiber mechanics and ventricular function. Regional variation of action potential duration is mainly due to differences on the density of membrane ionic currents like IK s and I to due to the regional heterogeneous density of KChIP2, Kv1.4, KvLQt1 and MinK. Multi‐scale computational models are useful to understand why such heterogeneities are important and the way in which they impact the whole organ function.