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Parathyroid Hormone, Platelet Free Cytosolic Calcium and Platelet Indices among Asian Indian and Qatari Subjects
Author(s) -
Afifi Nahla M.,
Ewis Soliman A.,
Benslimane Fatiha M.,
Bejaoui Yosra R.,
Alghafer Aisha
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1048.5
Subject(s) - mean platelet volume , medicine , platelet activation , platelet , parathyroid hormone , endocrinology , thrombus , hormone , calcium , coronary artery disease , cardiology
Asian Indians (AI) are more prone to coronary artery disease (CAD) than other ethnic groups. These variations in events are not fully explained only by differences in conventional cardiovascular risk factors. Thus, other factors must be account for such pattern. Disturbed some of the platelet activation indices including mean platelet volume (MPV) & platelet distribution width (PDW) as well as increased platelet free cytosolic calcium (Ca i ) play critical roles in platelet activation and thrombus formation. Parathyroid hormone (PTH) may increase risk for ischemic arrhythmias and its effects on MPV, PDW and Ca i is of growing interest. There are limited data concerning these parameters in AI. Therefore we aimed to study the PTH and platelet Ca i levels as well as MPV and PDW in healthy AI versus Qatari (Qt) subjects. Twelve healthy, nonsmoking AI were age matched with 11 healthy nonsmoking Qt subjects. PTH levels, as measured by ELISA, demonstrated a significant higher levels in AI (32.7±10.3 vs 23.5±9.95, P <0.05). Platelet Ca i , as measured by X ray microanalysis, exhibited a non‐significant increase among AI subjects compared with Qt ones (0.117±0.0854 vs 0.097±0.034, P =0.366). MPV and PDW were elevated among AI versus Qt subjects (MPV, 7.865±0.57 vs 7.7±0.294, P =0.284)) & (PDW, 15.929±0.369 vs 15.4±0.698, P <0.05). These differences may clarify the reported discrepancy in CAD rates between the two ethnic groups.