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ESTROGEN RECEPTOR CONTRIBUTES TO SEX DIFFERENCES IN ACUTE KIDNEY INJURY
Author(s) -
Ruiz Arnaldo Lopez,
Juncos Ramiro,
Chandrashekar Kiran,
Liu Ruisheng,
Reckelhoff Jane F.,
Juncos Luis A.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1041.16
Subject(s) - medicine , acute kidney injury , estrogen receptor , estrogen , creatinine , urology , renal function , endocrinology , blockade , kidney , receptor , cancer , breast cancer
Gender may influence the susceptibility and severity of various renal diseases. We evaluated sex difference, and the role of the estrogen receptor, in the hemodynamic and inflammatory responses to renal ischemia‐reperfusion induced‐acute kidney injury (I/R‐AKI). Adult Sprague‐Dawley rats were randomized into 4 groups (n=6–7/group), 1) Male Sham (M‐SHAM), 2) Female Sham (F‐SHAM), 3) Male‐ I/R‐AKI (M‐I/R‐AKI), 4) Female I/R‐AKI (F‐I/R‐AKI). I/R‐AKI was induced by bilateral clamping of the renal pedicles for 40min. Measurements were obtained 72 hrs after I/R‐AKI.Cortical‐RBF (TPU) OM‐RBF (TPU) CrCl (ml/min/g) NGAL (UI/ml) IL‐10 (pg/mg) HO Activity (pM Bilir./mg)M‐SHAM (6) 34.7±4.5 16.9±3.0 1.00±0.03 700±181 1.9±0.1 52±8 F‐SHAM (7) 32.9±1.4 22.6±1.0 1.02±0.10 1400±240 # 3.1±0.3 # 90±5 # M‐I/R‐AKI (6) 13.2±2.6 11.4±1.3 0.16±0.01 3400±138 0.9±0.05 213±10 F‐I/R‐AKI (7) 15.3±2.8 17.6±1.5 * 0.47±0.03 * 4087±47 * 2.1±0.1 * 553±37 *(n). Data are Mean±SEM. * p<0.05 vs M‐I/R‐AKI. # p<0.05 vs M‐SHAM CrCl = Creatinine Clearance; OM‐RBF = Outer Medullary‐RBFIn addition, estrogen receptor blockade in females decreased IL‐10 and HO activity, and worsened the parameters of renal function. Our data suggest that females, via estrogen receptors, have enhanced tissue protective factors (IL‐10 and HO), which may contribute to less severe impairment of hemodynamic and functional abnormalities after I/R‐AKI.