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Estimation of vascular properties using noninvasive measurements and a mathematical model of the systemic arteries
Author(s) -
Rose William C.,
Edwards Jonathan W.,
Johnson David A.,
Stillabower Michael E.,
Edwards David G.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.1039.14
Subject(s) - femoral artery , medicine , blood pressure , vascular resistance , cardiology , aortic pressure , compliance (psychology) , artery , applanation tonometry , biomedical engineering , arterial stiffness , psychology , social psychology
The estimation of vascular properties is useful for physiological and clinical assessment. PURPOSE The purpose of this study was to estimate vascular properties under different physiological conditions using noninvasive measurements and a mathematical model of the arterial circulation. METHODS Blood pressure waveforms were recorded by applanation tonometry at the radial and femoral arteries in 21 individuals under control conditions, during a cold pressor test, and after administration of sublingual nitroglycerin. A mathematical model of the arterial circulation was used to predict femoral artery pressure wave from measured radial artery pressure wave. Three model parameters were adjusted to minimize the difference between estimated and measured femoral pressure. RESULTS Resistance vessel diameter profile, arterial resistance, blood volume, and aortic pressure depended significantly on the perturbation given (ANOVA, p<0.01), but cardiac output and total arterial compliance did not (p>0.05). The root mean square difference between the predicted and measured femoral waveforms was 6.8 ± 4.5 mmHg. CONCLUSIONS Vascular mechanical properties estimated under different conditions had realistic values. Some but not all estimated quantities showed significant variation when physiological conditions were altered. Supported by the University of Delaware Research Foundation.